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Basics of NUT Midline

What Causes NUT Midline Carcinoma


What Can Families Do

Basic Facts of NUT Midline Carcinoma

NUT midline carcinoma (NMC) is a rare and life-threatening type of cancer. It typically, but not always, affects the body’s “midline,” including the nose, mouth, sinuses, trachea, upper airways, chest, and thymus. NMC occurs in both children and adults. NMC is often resistant to treatment; currently the average survival from diagnosis is less than one year. NMC is named for and defined by a DNA mutation of the NUT gene. In all NMCs, NUT is fused to another gene, most commonly BRD4, forming the BRD4-NUT fusion oncogene. Described by our group in 2004, NMC is a newly recognized disease, and awareness within the medical community remains limited. NMC is under-diagnosed and its true frequency in the population is not known. An optimal approach to treating this cancer has not yet been developed. We have formed the International NUT Midline Carcinoma Registry to increase awareness of this disease and to learn more about what causes it and how to treat it.

If you would like more detailed information, feel free to read the Doctors section of this website.

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