Selected Publications

Stathis A., Zucca E., Bekradda M., Gomez-Roca C., Delord J.P., de La Motte Rouge T., Uro-Coste E., de Braud F., Pelosi G., French C.A. Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628. Cancer Discov. 2016 May;6(5):492-500. [pdf]

Alekseyenko A.A., Walsh E.M., Wang X., Grayson A.R., Hsi P.T., Kharchenko P.V., Kuroda M.I., French C.A. The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains. Genes Dev. 2015 Jul 15;29(14):1507-23. [pdf]

Chau N.G., Mitchell C.M., Aserlind A., Grunfeld N., Kaplan L., Bauer D.E., Lathan C.S., Rodriguez-Galindo C., Hurwitz S., Tishler R.B., Haddad R.I., Sallan S.E., Bradner J.E., French C.A. Aggressive treatment and survival outcomes in NUT midline carcinoma (NMC) of the head and neck (HN). Journal of Clinical Oncology. 2014 ASCO Annual Meeting Abstracts. May 20 Supplement 32 (No 15_suppl): 6057. [pdf]

French C.A., Rahman S., Walsh E.M., Kühnle S., Grayson A.R., Lemieux M.E., Grunfeld N., Rubin B.P., Antonescu C.R., Zhang S., Venkatramani R., Dal Cin P., Howley P.M. NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism. Cancer Discov. 2014 Aug;4(8):928-41. [pdf]

Bauer D.E., Mitchell C.M., Strait K.M., Lathan C.S., Stelow E.B., Lüer S.C., Muhammed S., Evans A.G., Sholl L.M., Rosai J., Giraldi E., Oakley R.P., Rodriguez-Galindo C., London W.B., Sallan S.E., Bradner J.E., French C.A. Clinicopathologic Features and Long-term Outcomes of NUT Midline Carcinoma. Clin Cancer Res. 2012 Oct 15;18(20):5773-9. [pdf]

French, C.A. Pathogenesis of NUT Midline Carcinoma. Annu Rev Pathol. 2012;7:247-65. [pdf]

Schwartz, B.E., Hofer, M.D., Lemieux, M.E., Bauer, D.E., Cameron, M.J., West, N.H., Agoston, E.S., Reynoird, N., Khochbin, S., Ince, T.A., Christie, A., Janeway, K.A., Vargas, S.O., Perez-Atayde, A.R., Aster, J.C., Sallan, S.E., Kung, A.L., Bradner, J.E., French, C.A. Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming. Cancer Res. 2011 Apr 1;71(7):2686-96. [pdf]

Filippakopoulos, P., Qi, J., Picaud, S., Shen, Y., Smith, W.B., Fedorov, O., Morse, E.M., Keates, T., Hickman, T.T., Felletar, I., Philpott, M., Munro, S., McKeown, M.R., Wang, Y., Christie, A.L., West, N., Cameron, M.J., Schwartz, B., Heightman, T.D., La Thangue, N., French, C.A., Wiest, O., Kung, A.L., Knapp, S., Bradner, J.E. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73. [pdf]

Reynoird, N., Schwartz, B.E., Delvecchio, M., Sadoul, K., Meyers, D., Mukherjee, C., Caron, C., Kimura, H., Rousseaux, S., Cole, P.A., et al. Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. EMBO J. 2010 Sep 1;29(17):2943-52. [pdf]

French, C.A. Demystified molecular pathology of NUT midline carcinomas. J Clin Pathol. 2010 Jun;63(6):492-6.

Haack H, Johnson LA, Fry CJ, Crosby K, Polakiewicz RD, Stelow EB, Seung-Mo Hong, Schwartz BE, Cameron MJ, Rubin MA, Chang MC, Aster JC, French CA. Diagnosis of NUT Midline Carcinoma Using a NUT-Specific Monoclonal Antibody. Am J Surg Pathol. 2009 Jul;33(7):984-91. [pdf]

Stelow, E.B., Bellizzi, A.M., Taneja, K., Mills, S.E., Legallo, R.D., Kutok, J.L., Aster, J.C., and French, C.A. NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract. Am J Surg Pathol. 2008 Jun;32(6):828-34.

French, C.A., Ramirez, C.L., Kolmakova, J., Hickman, T.T., Cameron, M.J., Thyne, M.E., Kutok, J.L., Toretsky, J.A., Tadavarthy, A.K., Kees, U.R., et al. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene. 2008 Apr 3;27(15):2237-42. [pdf]

Jang, M.K., Mochizuki, K., Zhou, M., Jeong, H.S., Brady, J.N., and Ozato, K. The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell. 2005 Aug 19;19(4):523-34.

French, C.A., Miyoshi, I., Kubonishi, I., Grier, H.E., Perez-Atayde, A.R., and Fletcher, J.A. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. [pdf]

Yang, Z., Yik, J.H., Chen, R., He, N., Jang, M.K., Ozato, K., and Zhou, Q. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell. 2005 Aug 19;19(4):535-45.

Dey, A., Ellenberg, J., Farina, A., Coleman, A.E., Maruyama, T., Sciortino, S., Lippincott-Schwartz, J., and Ozato, K. A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition. Mol Cell Biol. 2000 Sep;20(17):6537-49.

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